Oral amphotericin B therapy in deep-seated mycoses
نویسندگان
چکیده
منابع مشابه
Deep seated Candidiasis
Candida pneumonia is classified as primary when there is no other hematogenous manifestation of candidiasis. The infection is rare and usually is the result of aspiration. Secondary candida pneumonia, the most frequent presentation, is associated with hematogenous candidiasis. Among cancer patients, only 9% of pulmonary candidiasis cases were considered primary. Cardiovascular infections caused...
متن کاملOral Amphotericin B: Challenges and Avenues
Amphotericin B (AmB) is a polyene antibiotic, widely used against life threatening systemic infections with fungi such as Candida albicans or Aspergillus fumigates as well as parasite such as Leishmania donovani. Until recently, AmB has been administered parenterally; however, this approach has been associated with significant infusion-related side effects and nephrotoxicity. Nevertheless, the ...
متن کاملActivity of MS-8209, a nonester amphotericin B derivative, in treatment of experimental systemic mycoses.
The in vitro and in vivo toxicities and activities of MS-8209, a new hydrosoluble amphotericin B (deoxycholate-amphotericin B [D-AmB]; Fungizone) derivative, were studied. In vitro, MS-8209 was less toxic than AmB against renal tubular cells in primary culture and less active against Candida albicans and Cryptococcus neoformans. However, at 10-fold the AmB concentration, MS-8209 in vitro antifu...
متن کاملRole of liposomal amphotericin B (AmBisome) in the prophylaxis of mycoses after liver transplantation.
The incidence of invasive fungal infection (IFI) after liver transplantation (LTx) ranges from 5 to 42% [1]. Candida albicans and Aspergillus fumigatus are the most common pathogens in liver graft recipients, who are more susceptible to IFIs than any other type of solid organ transplant recipient. Onset of fungal infection is mainly within the first two months after LTx which is associated with...
متن کاملRandomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia.
Objectives To prevent invasive fungal disease (IFD) in adult patients undergoing remission-induction chemotherapy for newly diagnosed acute lymphoblastic leukaemia (ALL). Patients and methods In a double-blind multicentre Phase 3 study, patients received prophylactic liposomal amphotericin B (L-AMB) at 5 mg/kg intravenously or placebo twice weekly in a 2:1 random allocation during remission-i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Medical Mycology
سال: 1969
ISSN: 1884-6971,0583-0516
DOI: 10.3314/jjmm1960.10.199